I'll second this, and since Ubuntu 10.10 is officially released as of today, I suppose it's appropriate to report this. My bug is somewhat different (although I think related), and it happens all the time. I'll log into a server with Mangler, using PTT on my mouse, using a USB headset for my audio input, and my onboard audio for output to speakers (I only have this headset as a USB mic, because the headphones on it are broken, and it's the only mic I have). It's a bit of an odd setup, I know, but prior to upgrading to 10.10 from 10.04 it worked flawlessly.
Anyway, everything works fine for about 2 or 3 minutes, sometimes longer, using either Pulse or ALSA. Then, my input will stop working (but I will still light up like it's working fine when I PTT). I can still receive just fine, but everyone says I can no longer be heard when this happens. To remedy the problem, I close Mangler. Upon closing, I'm told that everything I previously said during this problem input time will come through all at once in one big stream. At first I thought the problem was simply network lag, but this is very reproducible, which believes me it's tied to the input going "dead" until Mangler is closed. If I reopen Mangler, all seems to work well from that point on, but again only for another 2 or 3 minutes.
Any insight or patches on the matter would be greatly appreciated. Don't get my wrong, I think you guys have created an awesome piece of software, given the circumstances. I just wanted to let you know so perhaps it could be fixed. Thanks in advance.